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KMID : 0357919800140020015
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Korean Journal of Pathology
1980 Volume.14 No. 2 p.15 ~ p.20
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A Study on the Mechanism of Generalized Shwartzman Reaction
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이수영/Soo Young Lee
김원일/장성근/김주성<주임교수:김영제>/Won Il Kim/Sung Keun Chang/Choo Soung Kim
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Abstract
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The anti-rabbit plasma coagulation factor ?I goat immunoglobulin infusion, prevents
the generalized Shwartzman reaction of rabbits elicited by two 24 hours interval intrav-
enous injections of bacterial endotoxin. Measurements of circulating platelets, fibrinogen
and factor ?I activities were done after either the first or second injection of endotoxin
in both antibody-treated and non-treated rabbits. Twenty four hours after the first
injection of endotoxin, a marked increase of platelet was occurred in antibody-treated
rabbits, however an increase in fibrinogen was appeared in non-treated ones and forty
eight hours after the injection an increase in fibrinogen was greater in antibody-treated
group than in non-treated group. Forty eight hours after the first injection of endotoxin,
plasma factor ?I activities were decreased in non-treated rabbits. The occurrence of
bilateral cortical necrosis was confirmed in four out of five rabbits in non-treated group,
whereas no bilateral cortical necrosis was occurred in antibody-treated group.
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